About: Oral Picoplatin     Goto   Sponge   Distinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Oral Picoplatin
rdfs:subClassOf
Semantic_Type
  • Inorganic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Oral Picoplatin
NCI_META_CUI
  • CL374343
PDQ_Open_Trial_Search_ID
  • 551562
PDQ_Closed_Trial_Search_ID
  • 551562
Legacy_Concept_Name
  • Oral_Picoplatin
FULL_SYN
  • Oral PicoplatinPTNCI
  • Picoplatin (Oral)SYNCI
DEFINITION
  • An oral preparation of picoplatin, a third generation platinum compound with antineoplastic activity. Designed to overcome platinum drug resistance, picoplatin alkylates DNA, forming both inter- and intra-strand cross-linkages, resulting in inhibition of DNA replication and RNA transcription and the induction of apoptosis. Because of the increase in steric bulk around the platinum center, there is a relative reduction in the inactivation of picoplatin by thiol-containing species such as glutathione and metallothionein in comparison to cisplatin.NCI
code
  • C68924
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