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An Entity of Type : owl:DeprecatedClass, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Limonene
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Limonene
OLD_PARENT
  • Terpene
UMLS_CUI
  • C0064992
CAS_Registry
  • 138-86-3
Concept_Status
  • Retired_Concept
Contributing_Source
  • CRCH
ALT_DEFINITION
  • A terpene with two isoprene units forming a ring. The chemical structure is CC1=CCC(CC1)C(=C)C.CRCH
Chemical_Formula
  • C10H16
Legacy_Concept_Name
  • Limonene
FULL_SYN
  • 1-methyl-4-prop-1-en-2-yl-cyclohexeneSNNCI
  • LimonenePTCRCH
  • (4R)-1-methyl-4-prop-1-en-2-yl-cyclohexeneSYCRCH
  • LimonenePTNCI
DEFINITION
  • An oral dietary supplement containing a natural cyclic monoterpene and major component of the oil extracted from citrus peels with potential chemopreventive and antitumor activities. Although the mechanism of action has yet to be fully elucidated, limonene and its metabolites perillic acid, dihydroperillic acid, uroterpenol and limonene 1,2-diol may inhibit tumor growth through inhibition of p21-dependent signaling and may induce apoptosis via the induction of the transforming growth factor beta-signaling pathway. In addition, they inhibit post-translational modification of signal transduction proteins, resulting in G1 cell cycle arrest as well as differential expression of cell cycle- and apoptosis-related genes.NCI
DesignNote
  • Tue Feb 28 12:22:20 EST 2012 - See 'DL-Limonene'
code
  • C68543
sameAs
http://linked.open...y/mesh/hasConcept
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