About: Quinacrine Hydrochloride

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Quinacrine Hydrochloride
rdfs:subClassOf	ANTINEOPLASTICS ANTIPROTOZOALS
Has_Free_Acid_Or_Base_Form	QUINACRINE
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance
Preferred_Name	Quinacrine Hydrochloride
NSC_Code	14229
UMLS_CUI	C0282331
CAS_Registry	6151-30-0
In_Clinical_Trial_For	Prostate cancer
FDA_UNII_Code	G6242H2NAA
Contributing_Source	FDA
PDQ_Open_Trial_Search_ID	531122
PDQ_Closed_Trial_Search_ID	531122
Chemical_Formula	C23H30ClN3O.2ClH.2H2O
Legacy_Concept_Name	Quinacrine_Dihydrochloride
FULL_SYN	Atabrine DihydrochlorideSYNCI Quinacrine HydrochloridePTNCI Mepacrine DihydrochlorideSYNCI Quinacrine DihydrochlorideSYNCI QUINACRINE HYDROCHLORIDEPTFDAG6242H2NAA SN 390CNNCI 6-Chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxyacridine DihydrochlorideSNNCI
DEFINITION	The dihydrochloride salt of the 9-aminoacridine derivative quinacrine with potential antineoplastic and antiparasitic activities. Quinacrine may inhibit the transcription and activity of both basal and inducible nuclear factor-kappaB (NF-kappaB), which may result in the induction of tumor suppressor p53 transcription, the restoration of p53-dependent apoptotic pathways, and tumor cell apoptosis. Continuous NF-kappaB signaling, present in many tumors and in chronic inflammatory processes, promotes the expression of antiapoptotic proteins and cytokines while downregulating the expression of proapoptotic proteins, such as p53.NCI
code	C67059
sameAs	QUINACRINE HYDROCHLORIDE
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0018332
is Has_Salt_Form of	QUINACRINE
is sameAs of	QUINACRINE HYDROCHLORIDE QUINACRINE HYDROCHLORIDE QUINACRINE HYDROCHLORIDE

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