About: Elotuzumab     Goto   Sponge   Distinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Elotuzumab
rdfs:subClassOf
Has_Target
Concept_In_Subset
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Immunologic Factor
Preferred_Name
  • Elotuzumab
UMLS_CUI
  • C1832049
CAS_Registry
  • 915296-00-3
In_Clinical_Trial_For
  • Multiple Myeloma
FDA_UNII_Code
  • 1351PE5UGS
Contributing_Source
  • FDA
ALT_DEFINITION
  • A monoclonal antibody being studied in the treatment of advanced multiple myeloma. Monoclonal antibodies are made in the laboratory and can locate and bind to substances in the body, including cancer cells. HuLuc63 binds to CS1, a protein that is found mainly on the surface of multiple myeloma cells.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 532249
PDQ_Closed_Trial_Search_ID
  • 532249
Legacy_Concept_Name
  • Anti-CS1_Monoclonal_Antibody_HuLuc63
FULL_SYN
  • HuLuc63PTNCI-GLOSSCDR0000537332
  • PDL063CNNCI
  • PDL-063CNNCI
  • HuLuc63ABNCI
  • ELOTUZUMABPTFDA1351PE5UGS
  • BMS-901608CNNCI
  • ElotuzumabPTNCI
DEFINITION
  • A humanized monoclonal antibody directed against the human CS1 (CD2 subset 1, CRACC, SLAMF7) antigen with potential antineoplastic activity. Elotuzumab binds to the CS1 antigen, which may trigger antibody-dependent cellular cytotoxicity (ADCC) in cells expressing CS1. CS1 is a cell surface glycoprotein belonging to the CD2 subset of the immunoglobulin superfamily (IgSF) and is highly expressed by multiple myeloma cells, but minimally expressed by normal cells.NCI
code
  • C66982
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