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AttributesValues
rdf:type
rdfs:label
  • Penciclovir
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Penciclovir
UMLS_CUI
  • C0164815
CAS_Registry
  • 39809-25-1
FDA_UNII_Code
  • 359HUE8FJC
Contributing_Source
  • FDA
Chemical_Formula
  • C10H15N5O3
Legacy_Concept_Name
  • Penciclovir
CHEBI_ID
  • CHEBI:7956
FULL_SYN
  • 9-(4-Hydroxy-3-(hydroxymethyl)butyl)guanineSNNCI
  • PenciclovirPTNCI
  • 6H-Purin-6-one, 2-amino-1,9-dihydro-9-(4-hydroxy-3-(hydroxymethyl)butyl)-SNNCI
  • DenavirBRNCI
  • BRL 39123CNNCI
  • BRL-39123CNNCI
  • PENCICLOVIRPTFDA359HUE8FJC
  • CCRIS 9213CNNCI
DEFINITION
  • A synthetic acyclic guanine derivative with antiviral activity, mainly used to treat infections from herpes simplex virus (HSV) types 1 and 2. In HSV infected cells, penciclovir is phosphorylated by viral thymidine kinase and subsequently converted by cellular kinases into the active metabolite, penciclovir triphosphate, which competitively inhibits viral HSV polymerase by blocking deoxyguanosine triphosphate substrate binding. As a result, herpes viral DNA synthesis and replication are selectively inhibited.NCI
code
  • C66337
sameAs
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