About: Neridronic Acid     Goto   Sponge   Distinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Neridronic Acid
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Neridronic Acid
UMLS_CUI
  • C1882065
CAS_Registry
  • 79778-41-9
FDA_UNII_Code
  • 8U27U3RIN4
Contributing_Source
  • FDA
Chemical_Formula
  • C6H17NO7P2
Legacy_Concept_Name
  • Neridronic_Acid
FULL_SYN
  • NERIDRONIC ACIDPTFDA8U27U3RIN4
  • (6-Amino-1-hydroxyhexylidene)diphosphonic AcidSNNCI
  • Neridronic AcidPTNCI
DEFINITION
  • A third-generation, aminohexane bisphosphonate with anti-resorptive and anti-hypercalcemic activities. Although the exact mechanism of action has yet to be fully elucidated, neridronic acid binds to and adsorbs onto hydroxyapatite crystals in bone matrix, thereby preventing osteoclast resorption. This agent also binds to and inhibits farnesyl pyrophosphate synthase, an enzyme that plays an important role in the mevalonate pathway. This inhibits the formation of isoprenoids that are substrates for protein prenylation. This prevents farnesylation and geranylgeranylation of proteins essential for osteoclast function, thereby leading to the induction of apoptosis of osteoclasts. By preventing osteoclast-mediated bone resorption, neridronic acid decreases bone turnover rate, stabilizes the bone matrix and reduces hypercalcemia.NCI
code
  • C66230
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