About: Incadronic Acid     Goto   Sponge   Distinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Incadronic Acid
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Incadronic Acid
UMLS_CUI
  • C0287412
CAS_Registry
  • 124351-85-5
FDA_UNII_Code
  • G5C4M8847E
Contributing_Source
  • FDA
Chemical_Formula
  • C8H19NO6P2
Legacy_Concept_Name
  • Incadronic_Acid
FULL_SYN
  • INCADRONIC ACIDPTFDAG5C4M8847E
  • Incadronic AcidPTNCI
  • ((Cycloheptylamino)methylene)diphosphonic AcidSNNCI
  • YM175CNNCI
DEFINITION
  • A third-generation amino-bisphosphonate with anti-resorptive activity. Although the exact mechanism of action has yet to be fully elucidated, incadronic acid binds to and adsorbs onto hydroxyapatite crystals in the bone matrix, thereby preventing osteoclast resorption. This agent also binds to and inhibits farnesyl pyrophosphate synthase, an enzyme that plays an important role in the mevalonate pathway. This inhibits the formation of isoprenoids that are essential for protein prenylation. This prevents farnesylation and geranylgeranylation of proteins essential for osteoclast function, thereby leading to the induction of apoptosis of osteoclasts. By preventing osteoclast-mediated bone resorption, incadronic acid prevents bone destruction.NCI
code
  • C65906
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