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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Plicamycin
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Antibiotic
  • Organic Chemical
Preferred_Name
  • Plicamycin
NSC_Code
  • 24559
UMLS_CUI
  • C0026234
CAS_Registry
  • 18378-89-7
FDA_UNII_Code
  • NIJ123W41V
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to treat some types of testicular cancer. It is also used to treat a higher-than-normal amounts of calcium in the blood or urine. Plicamycin binds to DNA and prevents cells from making RNA and proteins. It is a type of antineoplastic antibiotic.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 41738
PDQ_Closed_Trial_Search_ID
  • 41738
Chemical_Formula
  • C52H76O24
Legacy_Concept_Name
  • Plicamycin
CHEBI_ID
  • CHEBI:31856
FULL_SYN
  • MTHABNCI
  • MithramycinSYNCI
  • plicamycinPTNCI-GLOSSCDR0000463729
  • A-2371SYDTPNSC0024559
  • PA-144SYDTPNSC0024559
  • Aureolic acidSYNCI
  • mithramycinPTNCI-GLOSSCDR0000476348
  • Aureolic acidSYDTPNSC0024559
  • A-2371CNNCI
  • PA-144CNNCI
  • MithracinSYDTPNSC0024559
  • PLICAMYCINPTFDANIJ123W41V
  • MithracinBRNCI
  • MithracinPTNCI-GLOSSCDR0000484118
  • MithracineFBNCI
  • PlicamycinPTNCI
DEFINITION
  • An antibiotic isolated from the bacterium Streptomyces plicatus with antineoplastic activity. Plicamycin, also known as mithramycin, binds to the minor groove of DNA at GC-rich sites, resulting in inhibition of RNA synthesis; this agent also inhibits mRNA expression, resulting in a reduction in protein synthesis. In addition, plicamycin may inhibit bone resorption by down regulating transcription of c-src, an oncogene involved in bone metabolism and resorption. (NCI04)NCI
code
  • C658
sameAs
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