About: Chloroquine Hydrochloride     Goto   Sponge   Distinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Chloroquine Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Chloroquine Hydrochloride
UMLS_CUI
  • C1383389
CAS_Registry
  • 3545-67-3
FDA_UNII_Code
  • NT0J0815S5
Contributing_Source
  • FDA
Chemical_Formula
  • C18H26ClN3.2HCl
Legacy_Concept_Name
  • Chloroquine_Hydrochloride
FULL_SYN
  • Chloroquine HydrochloridePTNCI
  • CHLOROQUINE HYDROCHLORIDEPTFDANT0J0815S5
DEFINITION
  • The hydrochloride salt of chloroquine, a synthetic quinoline with antimalarial and anti-inflammatory properties. Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum. Although the mechanism of action is not fully understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. Chloroquine may also interfere with the biosynthesis of nucleic acids.NCI
code
  • C65318
is Has_Salt_Form of
is sameAs of
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