About: MAGE-A1, Her-2/neu, FBP Peptides Cancer Vaccine     Goto   Sponge   Distinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • MAGE-A1, Her-2/neu, FBP Peptides Cancer Vaccine
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
  • Immunologic Factor
Preferred_Name
  • MAGE-A1, Her-2/neu, FBP Peptides Cancer Vaccine
UMLS_CUI
  • C1831955
In_Clinical_Trial_For
  • HER2/neu expressing advanced malignancies.
PDQ_Open_Trial_Search_ID
  • 506045
PDQ_Closed_Trial_Search_ID
  • 506045
Legacy_Concept_Name
  • MAGE-A1_Her-2_neu_FBP_Peptide_Cancer_Vaccine
FULL_SYN
  • MAGE-A1, Her-2/neu, FBP Peptides Ovarian Cancer VaccineSYNCI
  • MAGE-A1, Her-2/neu, FBP Peptides Cancer VaccinePTNCI
DEFINITION
  • A synthetic cancer vaccine comprised of multiple peptides derived from MAGE-1A, Her-2/neu, and folate binding protein (FBP), with potential immunostimulating and antineoplastic properties. MAGE-A1, Her-2/neu, and FBP proteins are simultaneously over-expressed in various cancer cell types, such as epithelial ovarian cancer. The MAGE-A1, Her-2/neu, FBP peptides cancer vaccine includes the peptides MAGE-A1:161-169, FBP:191-199, Her-2/neu:369-377, MAGE-A1:96-104, and Her-2/neu:754-762. Vaccination with this cancer vaccine may activate the immune system to mount a cytotoxic T-cell (CTL) response against tumor cells expressing the corresponding antigens, resulting in tumor cell lysis.NCI
code
  • C62775
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