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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Quinapril
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Quinapril
UMLS_CUI
  • C0072857
CAS_Registry
  • 85441-61-8
FDA_UNII_Code
  • RJ84Y44811
Contributing_Source
  • FDA
Chemical_Formula
  • C25H30N2O5
Legacy_Concept_Name
  • Quinapril_Base
CHEBI_ID
  • CHEBI:8713
FULL_SYN
  • QUINAPRILPTFDARJ84Y44811
  • QuinaprilPTNCI
DEFINITION
  • A prodrug and non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Quinapril is hydrolized into its active form quinaprilat, which binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This abolishes the potent vasoconstrictive actions of angiotensin II and leads to vasodilatation. Quinapril also causes a decrease in angiotensin II-induced aldosterone secretion by the adrenal cortex, thereby promoting diuresis and natriuresis, and increases bradykinin levels.NCI
code
  • C62074
sameAs
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