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AttributesValues
rdf:type
rdfs:label
  • Dextromethorphan
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Dextromethorphan
UMLS_CUI
  • C0011816
CAS_Registry
  • 125-71-3
FDA_UNII_Code
  • 7355X3ROTS
Contributing_Source
  • FDA
ALT_DEFINITION
  • The d-isomer of the codeine analog of LEVORPHANOL. Dextromethorphan shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is a NMDA receptor antagonist (RECEPTORS, N-METHYL-D-ASPARTATE) and acts as a non-competitive channel blocker. It is used widely as an antitussive agent, and is also used to study the involvement of glutamate receptors in neurotoxicity.MSH2002_06_01
Chemical_Formula
  • C18H25NO
Legacy_Concept_Name
  • Dextromethorphan_Base
CHEBI_ID
  • CHEBI:4470
FULL_SYN
  • DXMSYNCI
  • DEXTROMETHORPHANPTFDA7355X3ROTS
  • DextromethorphanPTNCI
DEFINITION
  • A synthetic, methylated dextrorotary analogue of levorphanol, a substance related to codeine and a non-opioid derivate of morphine. Dextromethorphan exhibits antitussive activity and is devoid of analgesic or addictive property. This agent crosses the blood-brain-barrier and activates sigma opioid receptors on the cough center in the central nervous system, thereby suppressing the cough reflex.NCI
code
  • C62022
sameAs
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