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AttributesValues
rdf:type
rdfs:label
  • Ceftriaxone
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Antibiotic
  • Organic Chemical
Preferred_Name
  • Ceftriaxone
UMLS_CUI
  • C0007561
CAS_Registry
  • 73384-59-5
FDA_UNII_Code
  • 75J73V1629
Contributing_Source
  • FDA
ALT_DEFINITION
  • An antibiotic drug used to treat infection. It belongs to the family of drugs called cephalosporin antibiotics.NCI-GLOSS
Chemical_Formula
  • C18H18N8O7S3
Legacy_Concept_Name
  • Ceftriaxone_Base
CHEBI_ID
  • CHEBI:29007
FULL_SYN
  • CeftriaxonePTNCI
  • ceftriaxonePTNCI-GLOSSCDR0000045335
  • CEFTRIAXONEPTFDA75J73V1629
DEFINITION
  • A beta-lactam, third-generation cephalosporin antibiotic with bactericidal activity. Ceftriaxone binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. Compared to the second and first generation cephalosporins, ceftriaxone is more active against gram-negative bacteria and less active against gram-positive bacteria. Ceftriaxone also crosses the blood-brain barrier and reaches therapeutic concentrations in the central nervous system (CNS).NCI
code
  • C62020
sameAs
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