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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Fluticasone
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Fluticasone
UMLS_CUI
  • C0082607
CAS_Registry
  • 90566-53-3
FDA_UNII_Code
  • CUT2W21N7U
Contributing_Source
  • FDA
Chemical_Formula
  • C22H27F3O4S
Legacy_Concept_Name
  • Fluticasone
FULL_SYN
  • FluticasonePTNCI
  • FLUTICASONEPTFDACUT2W21N7U
DEFINITION
  • A synthetic trifluorinated glucocorticoid receptor agonist with antiallergic, antiinflammatory and antipruritic effects. Fluticasone binds and activates glucocorticoid receptor, resulting in the activation of lipocortin. Lipocortin, in turn, inhibits cytosolic phospholipase A2, which triggers a cascade of reactions involved in the synthesis of inflammatory mediators, such as prostaglandins and leukotrienes. Secondly, mitogen-activated protein kinase (MAPK) phosphatase 1 is induced, thereby leads to dephosphorylation and inactivation of Jun N-terminal kinase directly inhibiting c-Jun mediated transcription. Finally, transcriptional activity of nuclear factor (NF)-kappa-B is blocked, thereby inhibits the transcription of cyclooxygenase 2, which is essential for prostaglandin production.NCI
code
  • C61767
sameAs
http://linked.open...y/mesh/hasConcept
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