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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Econazole
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Econazole
UMLS_CUI
  • C0013547
CAS_Registry
  • 27220-47-9
FDA_UNII_Code
  • 6Z1Y2V4A7M
Contributing_Source
  • FDA
Chemical_Formula
  • C18H15Cl3N2O
Legacy_Concept_Name
  • Econazole
CHEBI_ID
  • CHEBI:4754
FULL_SYN
  • ECONAZOLEPTFDA6Z1Y2V4A7M
  • EconazolePTNCI
DEFINITION
  • An imidazole with antifungal property. Econazole compromises the integrity of fungal cell wall through inhibiting 14-alpha demethylase, which catalyzes conversion of lanosterol to ergosterol, an essential component of the fungal cell wall. As a result, this agent increases cellular permeability thereby resulting in leakage of cellular contents. Furthermore, econazole has also been implicated to inhibit endogenous respiration, interact with membrane phospholipids, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.NCI
code
  • C61740
sameAs
http://linked.open...y/mesh/hasConcept
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