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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Nedaplatin
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Inorganic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Nedaplatin
UMLS_CUI
  • C0093999
CAS_Registry
  • 95734-82-0
FDA_UNII_Code
  • 8UQ3W6JXAN
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 468844
PDQ_Closed_Trial_Search_ID
  • 468844
Chemical_Formula
  • C2H2O3.Pt.2H3N
Legacy_Concept_Name
  • Nedaplatin
CHEBI_ID
  • CHEBI:31898
FULL_SYN
  • (Glycolato-O,O')diammineplatinum(II)SNNCI
  • NDPABNCI
  • CDGPABNCI
  • 254-SCNNCI
  • NEDAPLATINPTFDA8UQ3W6JXAN
  • cis-Diammine(glucolato)platinumSNNCI
  • NedaplatinPTNCI
DEFINITION
  • A second-generation cisplatin analogue with antineoplastic activity. Containing a novel ring structure in which glycolate is bound to the platinum by a bidentate ligand, nedaplatin forms reactive platinum complexes that bind to nucelophillic groups in DNA, resulting in intrastrand and interstrand DNA cross-links, apoptosis and cell death. This agent appears to be less nephrotoxic and neurotoxic compared to both cisplatin and carboplatin.NCI
code
  • C61099
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