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AttributesValues
rdf:type
rdfs:label
  • Indomethacin
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Indomethacin
NSC_Code
  • 77541
UMLS_CUI
  • C0021246
CAS_Registry
  • 53-86-1
Accepted_Therapeutic_Use_For
  • Dysmennorhea; Inflammatory disorders; Pain
In_Clinical_Trial_For
  • Advanced colorectal cancer
FDA_UNII_Code
  • XXE1CET956
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug that reduces pain, fever, swelling, and redness. It is also being used to reduce tumor-induced suppression of the immune system and to increase the effectiveness of anticancer drugs. It is a type of nonsteroidal anti-inflammatory drug (NSAID).NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 39489
PDQ_Closed_Trial_Search_ID
  • 39489
Chemical_Formula
  • C19H16ClNO4
Legacy_Concept_Name
  • Indomethacin
CHEBI_ID
  • CHEBI:49662
FULL_SYN
  • IndometacinSYNCI
  • IndomethacinPTNCI
  • 1-(4-chlorobenzoyl)-5-methoxy- 2-methyl-1-H-indole-3-acetic acidSNNCI
  • indomethacinPTNCI-GLOSSCDR0000045223
  • IndocinSYDTPNSC0077541
  • IndomethacinPTDCP00069
  • IndocinBRNCI
  • INDOMETHACINPTFDAXXE1CET956
DEFINITION
  • A synthetic nonsteroidal indole derivative with anti-inflammatory activity and chemopreventive properties. As a nonsteroidal anti-inflammatory drug (NSAID), indomethacin inhibits the enzyme cyclooxygenase, thereby preventing cyclooxygenase-mediated DNA adduct formation by heterocyclic aromatic amines. This agent also may inhibit the expression of multidrug-resistant protein type 1, resulting in increased efficacies of some antineoplastic agents in treating multi-drug resistant tumors. In addition, indomethacin activates phosphatases that inhibit the migration and proliferation of cancer cells and downregulates survivin, which may result in tumor cell apoptosis. (NCI04)NCI
code
  • C576
sameAs
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