About: Hydrocortisone Valerate     Goto   Sponge   Distinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Hydrocortisone Valerate
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Hydrocortisone Valerate
UMLS_CUI
  • C0063079
CAS_Registry
  • 57524-89-7
FDA_UNII_Code
  • 68717P8FUZ
Contributing_Source
  • FDA
Chemical_Formula
  • C26H38O6
Legacy_Concept_Name
  • Hydrocortisone_Valerate
CHEBI_ID
  • CHEBI:50865
FULL_SYN
  • Hydrocortisone ValeratePTNCI
  • HYDROCORTISONE VALERATEPTFDA68717P8FUZ
  • 11beta,17,21-Trihydroxypregn-4-ene-3,20-dione 17-ValerateSNNCI
  • WestcortBRNCI
DEFINITION
  • The valerate salt form of hydrocortisone, a synthetic glucocorticoid receptor agonist with antiinflammatory, antipruritic and vasoconstrictive effects. Binding and activation of the glucocorticoid receptor results in the activation of lipocortin that in turn inhibits cytosolic phospholipase A2. Lack of phospholipase A2 prevents the release of arachidonic acid, precursor for inflammatory mediator prostaglandins and leukotrienes, from the cell membrane. Secondly, mitogen-activated protein kinase (MAPK) phosphatase 1 is induced, thereby leads to dephosphorylation and inactivation of Jun N-terminal kinase directly inhibiting c-Jun mediated transcription. Finally, transcriptional activity of nuclear factor (NF)-kappa-B is blocked, thereby inhibits the transcription of cyclooxygenase 2, which is essential for prostaglandin production.NCI
code
  • C48024
sameAs
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