About: Pyridostigmine Bromide     Goto   Sponge   Distinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Pyridostigmine Bromide
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Pyridostigmine Bromide
NSC_Code
  • 679759
UMLS_CUI
  • C0034262
CAS_Registry
  • 101-26-8
FDA_UNII_Code
  • KVI301NA53
Contributing_Source
  • FDA
Chemical_Formula
  • C9H13N2O2.Br
Legacy_Concept_Name
  • Pyridostigmine_Bromide
FULL_SYN
  • Pyridostigmine BromidePTNCI
  • PYRIDOSTIGMINE BROMIDEPTFDAKVI301NA53
  • Carbamic Acid,Dimethyl-, Ester with 3-Hydroxy-1-methylpyridinium BromideSNNCI
  • 3-Hydroxy-1-methylpyridinium Bromide DimethylcarbamateSNNCI
  • Mestinon BromideSYNCI
  • KaliminSYNCI
  • RegonalSYNCI
  • 3-(((Dimethylamino)carbonyl)oxy)-1-methylpyridinium BromideSNNCI
DEFINITION
  • The bromide salt form of pyridostigmine, a quaternary ammonium carbamate derivative and a acetylcholinesterase inhibitor. Pyridostigmine bromide binds reversibly to acetylcholinesterase active sites in the peripheral nervous system, thereby preventing the breakdown of acetylcholine. This leads to an accumulation of acetylcholine at cholinergic synapses and facilitates transmission of impulses across the neuromuscular junction. Mediated through muscarinic receptors, this agent increases contraction of bronchial and intestinal smooth muscle and the exocrine glands secretions, while it causes paralysis of the skeletal muscles mediated through nicotinic receptors . In addition, pyridostigmine is used as a reversible blocking agent to prevent organophosphates from binding to the acetylcholinesterase receptors and thereby protect the nervous system from the effects of nerve agents such as Soman.NCI
code
  • C47697
sameAs
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