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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Praziquantel
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Praziquantel
UMLS_CUI
  • C0032911
CAS_Registry
  • 55268-74-1
FDA_UNII_Code
  • 6490C9U457
Contributing_Source
  • FDA
Chemical_Formula
  • C19H24N2O2
Legacy_Concept_Name
  • Praziquantel
CHEBI_ID
  • CHEBI:45267
FULL_SYN
  • PRAZIQUANTELPTFDA6490C9U457
  • PraziquantelPTNCI
  • PraziquantelPTDCP582
  • 4H-Pyrazino(2,1-a)isoquinolin-4-one, 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-SNNCI
  • DroncitSYNCI
  • BiltricideBRNCI
DEFINITION
  • A pyrazinoisoquinoline derivative with anthelminthic property. Praziquantel increases the permeability of the tegument of susceptible worms, resulting in an influx and increase in intra-tegumental calcium leading to rapid contractions and paralysis of the worm's musculature through a subsequent increase in levels of calcium in the sarcoplasmic reticulum. In addition, vacuolization of the tegumental syncytium and blebbing results in tegument disintegration, leads to antigen exposure and elicit host defense responses to the worm. The result is the formation of granulomas and phagocytosis.NCI
code
  • C47683
sameAs
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