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AttributesValues
rdf:type
rdfs:label
  • Olanzapine
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Olanzapine
UMLS_CUI
  • C0171023
CAS_Registry
  • 132539-06-1
FDA_UNII_Code
  • N7U69T4SZR
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to treat certain mental disorders. It is also being studied in the treatment of nausea and vomiting caused by some cancer treatments. It is a type of antipsychotic and a type of monoamine antagonist.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 449664
PDQ_Closed_Trial_Search_ID
  • 449664
Chemical_Formula
  • C17H20N4S
Legacy_Concept_Name
  • Olanzapine
CHEBI_ID
  • CHEBI:7735
FULL_SYN
  • olanzapinePTNCI-GLOSSCDR0000476310
  • 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno(2,3-b)(1,5)benzodiazepineSNNCI
  • Zyprexa ZydisPTNCI-GLOSSCDR0000572213
  • ZydisSYNCI
  • ZyprexaPTNCI-GLOSSCDR0000572212
  • ZyprexaBRNCI
  • OLANZAPINEPTFDAN7U69T4SZR
  • LY 170053CNNCI
  • OlanzapinePTNCI
DEFINITION
  • A synthetic derivative of thienobenzodiazepine with antipsychotic, antinausea, and antiemetic activities. As a selective monoaminergic antagonist, olanzapine binds with high affinity binding to the following receptors: serotoninergic, dopaminergic, muscarinic M1-5, histamine H1, and alpha-1-adrenergic receptors; it binds weakly to gamma-aminobutyric acid type A, benzodiazepine, and beta-adrenergic receptors. The antinausea and antiemetic effects of this agent appear to be due to the blockade of 5-HT2 and 5-HT3 receptors for serotonin. Although its exact mechanism of action in schizophrenia is unknown, it has been proposed that olanzapine's antipsychotic activity is mediated through antagonism to dopamine D2 receptors with rapid ligand-receptor dissociation kinetics that help to minimize extrapyramidal symptoms (EPS). Olanzapine may also stimulate appetite.NCI
code
  • C47639
sameAs
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