About: CYP2D6*18 Allele     Goto   Sponge   Distinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • CYP2D6*18 Allele
rdfs:subClassOf
OMIM_Number
  • 124030
GenBank_Accession_Number
  • NM_000106
Semantic_Type
  • Gene or Genome
Preferred_Name
  • CYP2D6*18 Allele
PubMedID_Primary_Reference
  • 8946471
UMLS_CUI
  • C1707214
Legacy_Concept_Name
  • CYP2D6_18_Allele
FULL_SYN
  • Cytochrome P450, Family 2, Subfamily D, Polypeptide 6*18 AlleleSYNCI
  • CYP2D6, g.4125insGTGCCCACTSYNCI
  • CYP2D6*18 AllelePTNCI
  • CYP2D6*18SYNCI
  • CYP2D6(J9)SYNCI
Gene_Encodes_Product
  • Cytochrome P450 2D6
DEFINITION
  • Human CYP2D6*18 allele is located in the vicinity of 22q13.1 and is approximately 4 kb in length. This allele, a variant form of the CYP2D6 wild-type allele, encodes cytochrome P450 2D6*18 protein. The CYP2D6*18 allele exhibits a nine nucleotide insertion (g.4125insGTGCCCACT) in exon 9. This alteration increased the Km value of the cytochrome P450 2D6*18 protein toward bufuralol, resulting in decreased enzymatic activity.NCI
DesignNote
  • Ethnicity Association: Asian
code
  • C46050
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