About: CYP2C9*5 Allele     Goto   Sponge   Distinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • CYP2C9*5 Allele
rdfs:subClassOf
OMIM_Number
  • 601130
GenBank_Accession_Number
  • NM_000771
Semantic_Type
  • Gene or Genome
Preferred_Name
  • CYP2C9*5 Allele
PubMedID_Primary_Reference
  • 15289788
UMLS_CUI
  • C1707204
Legacy_Concept_Name
  • CYP2C9_5_Allele
FULL_SYN
  • Cytochrome P450, Family 2, Subfamily C, Polypeptide 9*5 AlleleSYNCI
  • CYP2C9, D360ESYNCI
  • CYP2C9*5 AllelePTNCI
  • CYP2C9, c.1080C>GSYNCI
  • CYP2C9*5SYNCI
Gene_Encodes_Product
  • Cytochrome P450 2C9
DEFINITION
  • Human CYP2C9*5 allele is located within 10q24 and is approximately 33 kb in length. This allele, a variant form of the CYP2C9 wild-type allele, encodes cytochrome P450 2C9*5 protein. The CYP2C9*5 allele exhibits a clinically-relevant SNP (c.1080C>G) in exon 7 that results in a D360E coding change. This alteration in the cytochrome P450 2C9*5 protein sequence increases the Km of this enzyme for (S)-warfarin, diclofenac, and lauric acid, thereby decreasing clearance of these drugs.NCI
DesignNote
  • Ethnicity Association: African American
code
  • C45615
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