About: Dacarbazine

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Dacarbazine
rdfs:subClassOf	Triazenes
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Dacarbazine
NSC_Code	45388
UMLS_CUI	C0010927
CAS_Registry	4342-03-4
Accepted_Therapeutic_Use_For	Carcinoid cancer; Hodgkins disease; Islet cell carcinoma; Melanoma; Neuroblastoma; Soft tissue sarcoma
In_Clinical_Trial_For	Hodgkins lymphoma; Melanoma; Neuroblastoma
FDA_UNII_Code	7GR28W0FJI
Contributing_Source	FDA
ALT_DEFINITION	A drug that is used to treat Hodgkin lymphoma and malignant melanoma and is being studied in the treatment of other types of cancer. It attaches to DNA in cells and may kill cancer cells. It is a type of alkylating agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID	39768
PDQ_Closed_Trial_Search_ID	39768
Chemical_Formula	C6H10N6O
Legacy_Concept_Name	Dacarbazine
CHEBI_ID	CHEBI:4305
FULL_SYN	DTICSYDTPNSC0045388 DacarbazinaSYNCI DacarbazinePTNCI 5-(dimethyltriazeno)imidazole-4-carboxamideSNNCI BiocarbazineSYNCI dacarbazinePTNCI-GLOSSCDR0000045260 5-(3-3-dimethyl-1-triazenyl)-1H-imidazole-4-carboxamideSNNCI 5(or 4)-(dimethyltriazeno)imidazole-4(or 5)-carboxamideSNNCI DICABNCI Imidazole carboxamideSYDTPNSC0045388 DTICABNCI 1H-imidazole-4-carboxamide, 5-(3,3-dimethyl-1-triazenyl)-SNNCI DeticeneSYDTPNSC0045388 4-(Dimethyltriazeno)imidazole-5-carboxamideSYDTPNSC0045388 5-(Dimethyltriazeno)imidazole-4-carboxamideSYDTPNSC0045388 Dimethyl Triazeno Imidazol CarboxamideSYNCI Imidazole Carboxamide DimethyltriazenoSYNCI Dacarbazine - DTICSYNCI DTIC-DomeSYDTPNSC0045388 Dimethyl Triazeno Imidazole CarboxamideSYNCI DacaticFBNCI AsercitFBNCI Dimethyl-triazeno-imidazole-carboximideSYNCI dimethyl-triazeno-imidazole carboxamideSYNCI DeticeneFBNCI Dimethyl (triazeno) imidazolecarboxamideSYNCI WR-139007CNNCI DTIC-DomePTNCI-GLOSSCDR0000635680 DACARBAZINEPTFDA7GR28W0FJI DTIC-DomeBRNCI Dacarbazina AlmirallSYNCI DetimedacFBNCI FauldeticFBNCI Imidazole CarboxamideSYNCI DakarbazinSYNCI
DEFINITION	A triazene derivative with antineoplastic activity. Dacarbazine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. (NCI04)NCI
code	C411
sameAs	DACARBAZINE DACARBAZINE
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0005636
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