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AttributesValues
rdf:type
rdfs:label
  • Terc Regulation Pathway
rdfs:subClassOf
Semantic_Type
  • Functional Concept
Preferred_Name
  • Terc Regulation Pathway
UMLS_CUI
  • C1515271
BioCarta_ID
  • h_tercPathway
ALT_DEFINITION
  • Telomerase is an enzyme that replicates the terminal sequences of eukaryotic chromosomes, namely the telomeres. Cells that have an unlimited replicative capacity, such as male germ cells and the majority of human cancers, have high levels of telomerase activity. The level and frequency of telomerase activity in more than 85% of all cancers highlights the critical role telomerase plays in tumor progression. Telomerase activation is the most common general marker for a cancer cell to date making it an attractive target for new cancer diagnostics and therapeutics. Human telomerase activity can be reconstituted in vitro by the essential RNA subunit, hTERC, and the catalytic protein component coded for by the hTERT gene. Both the human telomerase reverse transcriptase gene (hTERT) and the telomerase RNA gene (hTERC) are controlled at least in part at the transcriptional level. The hTERC gene is expressed at high levels in cancer cells, and is absent or at low levels in some normal tissues.BIOCARTA
Legacy_Concept_Name
  • Terc_Regulation_Pathway
FULL_SYN
  • Terc Regulation PathwayPTNCI
  • Overview of telomerase RNA component gene hTerc Transcriptional RegulationPTBIOCARTA
code
  • C39248
is someValuesFrom of
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