About: SRF Activation Pathway

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: SRF Activation Pathway Goto Sponge Distinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	SRF Activation Pathway
rdfs:subClassOf	Protein Activation Pathway
Semantic_Type	Functional Concept
Preferred_Name	SRF Activation Pathway
UMLS_CUI	C1519155
BioCarta_ID	h_malPathway
ALT_DEFINITION	Serum response factor (SRF) is a transcription factor, which binds to a serum response element (SRE) associated with a variety of genes including immediate early genes such as c-fos, fosB, junB, egr-1 and -2, neuronal genes such as nurr1 and nur77, and muscle genes such as actins and myosins. By regulating expression of these genes, SRF controls cell growth and differentiation, neuronal transmission, as well as muscle development and function. SRF can be activated by serum, lysophosphatidic acid (LPA), lipopolysaccharide (LPS), 12-O-tetradecanoylphorbol-13-acetate (TPA), cytokines, tumor necrosis factor-alpha (TNFalpha), agents that increase intracellular Ca2+, T-cell virus1 activator protein, hepatitis B virus activator proteins pX, activated oncogenes and protooncogenes, and extracellular stimuli such as antioxidant and UV light. In serum-starved cells, MAL is predominantly cytoplasmic where it is sequestered by actin monomers. Upon serum stimulation, Rho becomes active and, through its interaction with ROCK and mDia1, causes an accumulation of F-actin and a commensurate decrease in the level of G-actin. As a consequence, MAL is no longer sequestered and is free to translocate to the nucleus where it associates with SRF and activates SRE-mediated gene expression.BIOCARTA
Legacy_Concept_Name	SRF_Activation_Pathway
FULL_SYN	SRF Activation PathwayPTNCI Role of MAL in Rho-Mediated Activation of SRFPTBIOCARTA
code	C39145
is someValuesFrom of	nodeID://b643081 nodeID://b653768 nodeID://b658327 nodeID://b678695 nodeID://b678919 nodeID://b679712 nodeID://b685933 nodeID://b685954 nodeID://b688366 nodeID://b688472 nodeID://b688619 nodeID://b688705 nodeID://b688838 nodeID://b689116 nodeID://b689222 nodeID://b689317 nodeID://b689685 nodeID://b693306 nodeID://b706173 nodeID://b706320 nodeID://b706371 nodeID://b707162 nodeID://b707173 nodeID://b707535 nodeID://b709161 nodeID://b710977 nodeID://b712303 nodeID://b726331

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 48 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software