About: Segmentation Clock Pathway

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Attributes	Values
rdf:type	Class
rdfs:label	Segmentation Clock Pathway
rdfs:subClassOf	Cell Differentiation or Development Pathway
Semantic_Type	Functional Concept
Preferred_Name	Segmentation Clock Pathway
UMLS_CUI	C1519227
BioCarta_ID	h_hesPathway
ALT_DEFINITION	In most animal species, the anteroposterior body axis is generated by the formation of repeated structures called segments. In vertebrate segmentation, a specialized mesodermal structure called the somite gives rise to skeletal muscles, vertebrae, and some dermis. Formation of the somites is a rhythmic process that involves an oscillator, the segmentation clock, driven by Wnt and Notch signaling. The clock ticks in somite precursors and halts when they reach a specific maturation stage defined as the wavefront, established by FGF and Wnt signaling. Lunatic fringe was shown to act downstream of Notch and to bind and negatively regulate its own promoter. Another cyclic gene is hes1. It acts also downstream of Notch and codes for an unstable protein able to negatively regulate its own promoter too.BIOCARTA
Legacy_Concept_Name	Segmentation_Clock_Pathway
FULL_SYN	Segmentation ClockPTBIOCARTA Segmentation Clock PathwayPTNCI
code	C39104
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