About: Integrin Beta-3

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Integrin Beta-3
rdfs:subClassOf	nodeID://b683026
equivalentClass	nodeID://b634006
OMIM_Number	173470
Semantic_Type	Amino Acid, Peptide, or Protein
Preferred_Name	Integrin Beta-3
UMLS_CUI	C0638262
Legacy_Concept_Name	Integrin_Beta-3
FULL_SYN	CD61 AntigenSYNCI Antigen CD61SYNCI Platelet Membrane Glycoprotein IIIaSYNCI Integrin Beta Chain Beta 3SYNCI Integrin Beta-3PTNCI Platelet Glycoprotein IIIaSYNCI CD61SYNCI GP3ASYNCI ITGB3SYNCI GPIIIaSYNCI
Swiss_Prot	P05106
DEFINITION	Integrin beta-3 (788 aa, 87 kD) is a cell adhesion process protein that is encoded by the human ITGB3 gene and has roles in cell adhesion and blood coagulation.NCI
DesignNote	Widely expressed by human ITGB3 Gene (ITGB Family), type I membrane protein Integrin Beta 3 contains a VWFA-like domain and is involved in cell adhesion and signaling. Multiple heterodimeric alpha/beta combinations result in different integrins. ITGB3 associates with alphaIIB or alphaV and recognize RGD; aIIB/beta-3 also recognizes HHLGGGAKQAGDV in FN gamma. Beta-3C interacts with FLNB. aV/beta-3 is a receptor for cytotactin, fibronectin, laminin, MMP-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin, and von Willebrand factor. Receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin, and vitronectin, aIIB/beta-3 binds fibrinogen to induce platelet aggregation and plug ruptured endothelia. In response to platelet aggregation, Tyr-773/785 phosphorylated ITGB3 appears to bind GRB2/SHC. ITGB3 defects cause Glanzmann thrombasthenia (GT).
code	C38955
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0169857
is someValuesFrom of	nodeID://b643581

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