About: Nitric Oxide Synthase 2C     Goto   Sponge   Distinct   Permalink

An Entity of Type : owl:DeprecatedClass, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Nitric Oxide Synthase 2C
rdfs:subClassOf
OMIM_Number
  • 600720
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Enzyme
Preferred_Name
  • Nitric Oxide Synthase 2C
OLD_PARENT
  • Nitric_Oxide_Synthetase
OLD_ROLE
  • Gene_Product_Plays_Role_In_Biological_Process some 'Intercellular Communication Process'
  • Gene_Product_Encoded_By_Gene some 'NOS2C Gene'
  • Gene_Product_Plays_Role_In_Biological_Process some Oxidation/Reduction
  • Gene_Product_Has_Biochemical_Function some Oxidoreductase
UMLS_CUI
  • C1518335
Concept_Status
  • Retired_Concept
Legacy_Concept_Name
  • Nitric_Oxide_Synthase-2C
FULL_SYN
  • NOS Type IICSYNCI
  • Nitric Oxide Synthase 2CPTNCI
  • Nitric Oxide Synthase IICSYNCI
  • NOS2CSYNCI
  • NOSIICSYNCI
Swiss_Prot
  • Q14961
DEFINITION
  • Encoded by human NOS2C Gene (NOS Family), calcium/calmodulin stimulated homodimeric Nitric Oxide Synthase 2C binds FAD and FMN cofactors, requires BH4 which may stabilize the dimer, and synthesizes reactive free radical nitric oxide messenger (from L-arginine). NO has antimicrobial and antitumoral activities in macrophages. NOS2C may bind SLC9A3R1. IL12 requires NOS2 to stimulate NK cell cytotoxicity and to activate STAT4 tyrosine-phosphorylation by TYK2 in innate immunity. (NCI)NCI
DesignNote
  • Wed Sep 26 15:24:34 EDT 2012 - Q14961 has been designated Obsolete and deleted by UniProtKB/Swiss-Prot. The NOS2C gene is a pseudogene. No protein is encoded.
code
  • C38569
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