About: Clonidine     Goto   Sponge   Distinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Clonidine
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Clonidine
UMLS_CUI
  • C0009014
CAS_Registry
  • 4205-90-7
FDA_UNII_Code
  • MN3L5RMN02
Contributing_Source
  • FDA
ALT_DEFINITION
  • The active ingredient in a drug used to treat high blood pressure. It is also being studied in the treatment of certain types of cancer pain. It blocks the release of chemicals from nerve endings that make blood vessels constrict (get narrower). Clonidine is a type of antihypertensive agent and a type of alpha-adrenergic agonist.NCI-GLOSS
  • An alpha-2 adrenergic agonist that crosses the blood-brain barrier. Clonidine acts centrally by reducing sympathetic tone, resulting in a fall in diastolic and systolic blood pressure and a reduction in heart rate. It also acts peripherally, and this peripheral activity may be responsible for the transient increase in blood pressure seen during rapid intravenous administration. (From Martindale, the Extra Pharmacopoeia, 30th ed, p350)MSH2002_06_01
PDQ_Open_Trial_Search_ID
  • 41228
PDQ_Closed_Trial_Search_ID
  • 41228
Chemical_Formula
  • C9H9Cl2N3
Legacy_Concept_Name
  • Clonidine
CHEBI_ID
  • CHEBI:3757
  • CHEBI:46631
  • CHEBI:46632
FULL_SYN
  • N-(2,6-Dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amineSNNCI
  • Catapres-TTSBRNCI
  • N-(2,6-Dichlorophenyl)-4,5-dihydro-1H-imidazol-2-aminePTDCP06643
  • CLONIDINEPTFDAMN3L5RMN02
  • ClonidinePTNCI
  • clonidinePTNCI-GLOSSCDR0000630972
DEFINITION
  • An imidazoline derivate and centrally-acting alpha-adrenergic agonist, with antihypertensive activity. Clonidine binds to and stimulates central alpha-2 adrenergic receptors, thereby reducing the amount of norepinephrine (NE) release and thus decreasing sympathetic outflow to the heart, kidneys, and peripheral vasculature. The reduction in sympathetic outflow leads to decreased peripheral vascular resistance, decreased blood pressure, and decreased heart rate. In addition, clonidine binds to imidazoline receptor subtype 1 (I1), which may also contribute to a reduction in blood pressure.NCI
code
  • C380
sameAs
http://linked.open...y/mesh/hasConcept
is Has_Free_Acid_Or_Base_Form of
is sameAs of
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 58 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software