About: Receptor-Interacting Serine/Threonine-Protein Kinase 2

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Attributes	Values
rdf:type	Class
rdfs:label	Receptor-Interacting Serine/Threonine-Protein Kinase 2
equivalentClass	nodeID://b637652
OMIM_Number	603455
Semantic_Type	Amino Acid, Peptide, or Protein Enzyme
Preferred_Name	Receptor-Interacting Serine/Threonine-Protein Kinase 2
UMLS_CUI	C0759447
Legacy_Concept_Name	Receptor-Interacting_Serine-Threonine_Protein_Kinase-2
FULL_SYN	EC 2.7.10.2SYNCI EC 2.7.11.1SYNCI RIP-Like Interacting CLARP KinaseSYNCI RIP-Like-Interacting CLARP KinaseSYNCI CARD-Containing Interleukin-1 Beta Converting Enzyme Associated KinaseSYNCI Receptor-Interacting Serine/Threonine Protein Kinase 2SYNCI Receptor-Interacting Serine/Threonine-Protein Kinase 2PTNCI CARD-Containing IL-1 Beta Ice-KinaseSYNCI RIP2SYNCI RIPK2SYNCI Tyrosine-Protein Kinase RIPK2SYNCI Receptor Interacting Protein 2SYNCI Receptor-Interacting Protein 2SYNCI
Swiss_Prot	O43353
DEFINITION	Receptor-interacting serine/threonine-protein kinase 2 (540 aa, ~61 kDa) is encoded by the human RIPK2 gene. This protein is involved in protein phosphorylation, apoptosis and inflammation.NCI
DesignNote	Receptor-interacting serine/threonine-protein kinase 2 also has tyrosine kinase activity. (UniProt) Receptor-interacting serine/threonine-protein kinase 2 contains 1 CARD domain, activates NF-Kappa B and potentiates apoptosis by activating pro-caspase-1 and pro-caspase-8. RIPK2 binds to BIRC3/c-IAP1, BIRC2/c-IAP2, TRAF1, TRAF2, TRAF5, and TRAF6 and binds to CFLAR/CLARP and CASP1 via their CARD domains. RIPK2 may be a component of the TNFRSF1A and TNRFSF5/CD40 receptor complexes.
code	C29872
sameAs	Receptor-Interacting Protein Serine-Threonine Kinase 2
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0290667
is sameAs of	Receptor-Interacting Protein Serine-Threonine Kinase 2 Receptor-Interacting Protein Serine-Threonine Kinase 2

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