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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Rebamipide
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Rebamipide
UMLS_CUI
  • C0069562
CAS_Registry
  • 111911-87-6
  • 90098-04-7
FDA_UNII_Code
  • LR583V32ZR
Contributing_Source
  • FDA
Chemical_Formula
  • C19H15ClN2O4
Legacy_Concept_Name
  • Rebamipide
FULL_SYN
  • alpha-[(4-Chlorobenzoyl)amino]-1,2-dihydro-2-oxo-4-quinolinepropanoic AcidSNNCI
  • alpha-[(4-Chlorobenzoyl)amino]-1,2-dihydro-2-oxo-4-quinolinepropanoic AcidPTDCP09339
  • REBAMIPIDEPTFDALR583V32ZR
  • OPC 12759CNNCI
  • RebamipidePTNCI
DEFINITION
  • A quinolinone derivative with anti-ulcer and anti-inflammatory activities. Rebamipide induces cyclooxygenase 2 (COX2) synthesis which results in an increase in endogenous prostaglandin synthesis in the gastric mucosa. This agent also inhibits H. pylori-induced production of tumor necrosis factor (TNF) alpha and subsequent inflammation of the gastric mucosa. In addition, rebamipide scavenges oxygen-derived free radicals that potentially cause mucosal injury, and stimulates prostaglandin EP4 receptor gene expression followed by mucous secretion, thereby enhancing the gastric mucosal defense.NCI
code
  • C29852
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