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AttributesValues
rdf:type
rdfs:label
  • Mometasone Furoate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
  • Steroid
Preferred_Name
  • Mometasone Furoate
UMLS_CUI
  • C0066700
CAS_Registry
  • 83919-23-7
Accepted_Therapeutic_Use_For
  • Sinusitis
FDA_UNII_Code
  • 04201GDN4R
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug that is used in a cream to treat certain skin conditions and in a nasal spray to treat sinus problems caused by allergies. It is being studied as a way to treat inflammation of the skin caused by radiation therapy. Elocon is a type of corticosteroid.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 531049
PDQ_Closed_Trial_Search_ID
  • 531049
Chemical_Formula
  • C27H30Cl2O6
Legacy_Concept_Name
  • Mometasone_Furoate
CHEBI_ID
  • CHEBI:47564
FULL_SYN
  • mometasone furoatePTNCI-GLOSSCDR0000538643
  • Mometasone FuroatePTDCP20540
  • (11beta,16alpha)-9,21-Dichloro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methylpregna-1,4-diene-3,20-dioneSNNCI
  • EloconPTNCI-GLOSSCDR0000572208
  • EloconBRNCI
  • PropelBRNCI
  • NasonexPTNCI-GLOSSCDR0000572209
  • Mometasone FuroatePTNCI
  • NasonexBRNCI
  • MOMETASONE FUROATEPTFDA04201GDN4R
  • Sch-32088CNNCI
DEFINITION
  • The furoate salt form of mometasone, a synthetic topical glucocorticosteroid receptor agonist with anti-inflammatory, anti-pruritic and vasoconstrictive properties. Mometasone furoate exerts its effect by binding to cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor mediated gene expression. This results in synthesis of certain anti-inflammatory proteins, while inhibiting the synthesis of certain inflammatory mediators.. Specifically, mometasone furoate appears to induce phospholipase A2 inhibitory proteins, thereby controlling the release of the inflammatory precursor arachidonic acid from phospholipid membrane by phospholipase A2.NCI
code
  • C29268
sameAs
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