About: Monoclonal Antibody 1F5     Goto   Sponge   Distinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Monoclonal Antibody 1F5
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Immunologic Factor
Preferred_Name
  • Monoclonal Antibody 1F5
UMLS_CUI
  • C1513414
Legacy_Concept_Name
  • Monoclonal_Antibody_1F5
FULL_SYN
  • Anti-CD20 Monoclonal Antibody 1F5SYNCI
  • Monoclonal Antibody 1F5PTNCI
  • MOAB 1F5ABNCI
DEFINITION
  • A murine monoclonal antibody directed against CD20, a cross-membrane ion channel phosphoprotein expressed by B cells, with potential antineoplastic activity. MOAB 1F5 binds to CD20, thereby directly inhibiting B-cell proliferation and differentiation. When cross-linked by secondary anti-mouse antibodies or Fc receptor-bearing cells, MOAB 1F5 may induce activation of B-cell protein tyrosine kinases, increases in B-cell intracellular calcium ion concentrations, and B-cell caspase activation, resulting in apoptosis of B cells expressing CD20. (NCI04)NCI
code
  • C29198
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