About: Fluocinolone Acetonide     Goto   Sponge   Distinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Fluocinolone Acetonide
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
  • Steroid
Preferred_Name
  • Fluocinolone Acetonide
NSC_Code
  • 92339
UMLS_CUI
  • C0016298
CAS_Registry
  • 67-73-2
FDA_UNII_Code
  • 0CD5FD6S2M
Contributing_Source
  • FDA
Chemical_Formula
  • C24H30F2O6
Legacy_Concept_Name
  • Fluocinolone_Acetonide
FULL_SYN
  • Fluocinolone AcetonidePTNCI
  • FLUOCINOLONE ACETONIDEPTFDA0CD5FD6S2M
  • (6alpha,11beta,16alpha)-6,9-Difluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dioneSNNCI
  • Fluocinolone AcetonidePTDCP02011
DEFINITION
  • The acetonide salt form of fluocinolone, a synthetic fluorinated corticosteroid with antiinflammatory, antipruritic and vasoconstrictive properties. Fluocinolone is a glucocorticoid receptor agonist that binds to cytoplasmic glucocorticoid receptors and subsequently translocates to the nucleus where it initiates the transcription of glucocorticoid-responsive genes such as lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes, both are potent mediators of inflammation. Fluocinolone exerts its vasoconstrictive effect through inhibition of nitric oxide synthase, thereby blocking nitric oxide production and effectively diminishing the effect of nitric oxide on vascular smooth muscles leading to reduced blood flow.NCI
code
  • C29055
sameAs
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