About: Clobetasol Propionate     Goto   Sponge   Distinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Clobetasol Propionate
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Clobetasol Propionate
UMLS_CUI
  • C0055895
CAS_Registry
  • 25122-46-7
Accepted_Therapeutic_Use_For
  • Psoriasis, Eczema
FDA_UNII_Code
  • 779619577M
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 547027
PDQ_Closed_Trial_Search_ID
  • 547027
Chemical_Formula
  • C25H32ClFO5
Legacy_Concept_Name
  • Clobetasol_Propionate
CHEBI_ID
  • CHEBI:31414
FULL_SYN
  • CLOBETASOL PROPIONATEPTFDA779619577M
  • Olux-EBRNCI
  • Clobetasol PropionatePTDCP30204
  • Clobetasol PropionatePTNCI
DEFINITION
  • The propionate salt form of clobetasol, a topical synthetic corticosteroid with anti-inflammatory, anti-pruritic, and vasoconstrictive properties. Clobetasol propionate exerts its effect by binding to cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor mediated gene expression. This results in synthesis of certain anti-inflammatory proteins, while inhibiting the synthesis of certain inflammatory mediators. Specifically, clobetasol propionate appears to induce phospholipase A2 inhibitory proteins, thereby controlling the release of the inflammatory precursor arachidonic acid from membrane phospholipids by phospholipase A2.NCI
code
  • C28934
sameAs
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