About: Bisoprolol Fumarate     Goto   Sponge   Distinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Bisoprolol Fumarate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Bisoprolol Fumarate
UMLS_CUI
  • C0543473
CAS_Registry
  • 104344-23-2
FDA_UNII_Code
  • UR59KN573L
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 660819
PDQ_Closed_Trial_Search_ID
  • 660819
Chemical_Formula
  • 2C18H31NO4.C4H4O4
Legacy_Concept_Name
  • Bisoprolol_Fumarate
CHEBI_ID
  • CHEBI:3128
FULL_SYN
  • Bisoprolol HemifumarateSYNCI
  • Bisoprolol FumaratePTDCP01563
  • (+-)-1-((alpha-(2-Isopropoxyethoxy)-p-tolyl)oxy)-3-(isopropylamino)-2-propanol fumarate (2:1) (salt)SNNCI
  • Bisoprolol FumaratePTNCI
  • BISOPROLOL FUMARATEPTFDAUR59KN573L
DEFINITION
  • The fumarate salt of a synthetic phenoxy-2-propanol-derived cardioselective beta-1 adrenergic receptor antagonist with antihypertensive and potential cardioprotective activities. Devoid of intrinsic sympathomimetic activity, bisoprolol selectively and competitively binds to and blocks beta-1 adrenergic receptors in the heart, decreasing cardiac contractility and rate, reducing cardiac output, and lowering blood pressure. In addition, this agent may exhibit antihypertensive activity through the inhibition of renin secretion by juxtaglomerular epithelioid (JGE) cells in the kidney, thus inhibiting activation of the renin-angiotensin system (RAS). Bisoprolol has been shown to be cardioprotective in animal models.NCI
code
  • C28871
sameAs
http://linked.open...y/mesh/hasConcept
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