About: 9H-Purine-6Thio-98D     Goto   Sponge   Distinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • 9H-Purine-6Thio-98D
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
  • Nucleic Acid, Nucleoside, or Nucleotide
Preferred_Name
  • 9H-Purine-6Thio-98D
UMLS_CUI
  • C1515473
Legacy_Concept_Name
  • _9H-Purine-6Thio-98D
FULL_SYN
  • 9H-Purine-6Thio-98DPTNCI
DEFINITION
  • An antimetabolite analogue of purine with antineoplastic and immuno-suppressant properties. 9H-Purine-6Thio-98D substitutes for the normal nucleoside and fraudulently incorporates into DNA and inhibits de novo purine synthesis, thereby inducing cell death. In vivo, this agent, also known as 6MP-arabinoside, may occur as a metabolite of the antineoplastic agent mercaptopurine. (NCI04)NCI
code
  • C28793
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