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AttributesValues
rdf:type
rdfs:label
  • NY-ESO-B
rdfs:subClassOf
Semantic_Type
  • Immunologic Factor
Preferred_Name
  • NY-ESO-B
UMLS_CUI
  • C1327762
In_Clinical_Trial_For
  • Stage II or Stage III Melanoma
PDQ_Open_Trial_Search_ID
  • 257347
PDQ_Closed_Trial_Search_ID
  • 257347
Legacy_Concept_Name
  • NY-ESO-B
FULL_SYN
  • NY-ESO-BPTNCI
DEFINITION
  • A tumor-associated antigen belonging to the family of immunogenic testicular proteins that are aberrantly expressed in human cancers in a lineage-nonspecific fashion. Reverse transcription-PCR analysis showed NY-ESO-1 mRNA expression in a variable proportion of a wide array of human cancers, including melanoma, breast cancer, bladder cancer, prostate cancer, and hepatocellular carcinoma; and restricted expression in normal tissues, with high-level mRNA expression found only in testis and ovary tissues. The gene for NY-ESO-1 maps to Xq28 and codes for an 18-kDa protein having no homology with any known protein. NY-ESO-1 elicits a strong, integrated humoral and cellular immune response in a high proportion of patients with NY-ESO-1-expressing tumors and is under investigation as a cancer immunotherapy agent.NCI
code
  • C26680
is someValuesFrom of
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