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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Tocladesine
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Tocladesine
UMLS_CUI
  • C0050063
CAS_Registry
  • 41941-56-4
In_Clinical_Trial_For
  • Recurrent or Progressive Metastatic Colon Cancer and Recurrent or Refractory Multiple Myeloma.
FDA_UNII_Code
  • BQ94Z7E5OR
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance that is being studied as an anticancer drug. It is an analogue of a substance that occurs naturally in the body (cyclic adenosine monophosphate).NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 42670
PDQ_Closed_Trial_Search_ID
  • 42670
Chemical_Formula
  • C10H11ClN5O6P
Legacy_Concept_Name
  • Tocladesine
FULL_SYN
  • TocladesinePTNCI
  • 8-Chloroadenosine Cyclic 3':5'-MonophosphateSNNCI
  • tocladesinePTNCI-GLOSSCDR0000045537
  • TocladesinePTDCP20313
  • 8-Chloro Cyclic AMPSYNCI
  • 8-Cl-cAMPABNCI
  • TOCLADESINEPTFDABQ94Z7E5OR
  • AdenazoleSYNCI
DEFINITION
  • An antimetabolite and a chlorine derivative of the intracellular secondary messenger, cyclic adenosine 3,5-monophosphate (cAMP), with potential antineoplastic activity. Tocladesine appears to be converted to 8-chloro-adenosine by phosphodiesterases and subsequently phosphorylated to 8-chloro-ATP, which functions as a purine analogue and competes with ATP in transcription. In addition, generation of 8-chloro-ATP depletes endogenous ATP pool that is essential for many biological reactions in intracellular energy transfer. As a result, this agent causes RNA synthesis inhibition, blocks cellular proliferation, and induces apoptosis.NCI
code
  • C2571
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