About: Thomsen-Friedenreich Antigen     Goto   Sponge   Distinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Thomsen-Friedenreich Antigen
rdfs:subClassOf
Semantic_Type
  • Carbohydrate
  • Immunologic Factor
Preferred_Name
  • Thomsen-Friedenreich Antigen
UMLS_CUI
  • C0053438
PDQ_Open_Trial_Search_ID
  • 43470
PDQ_Closed_Trial_Search_ID
  • 43470
Legacy_Concept_Name
  • Thompson-Friedenreich_Antigen
FULL_SYN
  • TF(c)ABNCI
  • Thomsen-Friedenreich AntigenPTNCI
  • Antigen, Thomsen-FriedenreichSYNCI
DEFINITION
  • A type 1 core O-glycan with potential immunotherapeutic property. Thomsen-Friedenreich (TF) antigen, a galactose disaccharide, is normally O-linked to serine or threonine residue of mucins (MUC1), a transmembrane glycoprotein overexpressed on epithelial cell surface of a variety of tumor cells. The expression of this antigen is associated with tumor cell adhesion, tissue invasion and aggressiveness. When administered in a vaccine formulation, TF antigen may stimulate a cytotoxic T cell response against tumors expressing TF epitope, which may result in a reduction in tumor size.NCI
code
  • C2528
http://linked.open...y/mesh/hasConcept
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