About: Ad5CMV-p53 Gene

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Ad5CMV-p53 Gene
rdfs:subClassOf	Adenovirus Vaccines nodeID://b644277 nodeID://b644278 nodeID://b644279 nodeID://b644280 nodeID://b644281
Semantic_Type	Pharmacologic Substance Virus
Preferred_Name	Ad5CMV-p53 Gene
NSC_Code	683550
UMLS_CUI	C1135129
In_Clinical_Trial_For	Head and Neck cancer; Lip and oral cavity cancer; Oropharyngeal cancer
PDQ_Open_Trial_Search_ID	43016
PDQ_Closed_Trial_Search_ID	43016
Legacy_Concept_Name	Ad5CMV-p53_Gene
FULL_SYN	RPR/INGN-201CNNCI Adenovirus p53SYNCI Ad5CMV p53 GeneSYNCI Ad5CMV-p53 GenePTNCI p53 Gene, Ad5CMVSYNCI Ad-p53ABNCI AdvexinBRNCI INGN-201CNNCI Adeno-p53SYNCI
DEFINITION	A replication-defective adenoviral-CMV vector that encodes a wild-type p53 gene. Ad5CMV-p53 induces tumor cells that have been transfected with the vector to produce wild-type p53, a tumor suppressor gene that is deleted or mutated in a significant number of cancers. In transfected tumor cells, the wild-type p-53 gene product exerts an antitumor effect by blocking cell cycle progression at the G1/S regulation point, activating DNA repair proteins in the presence of DNA damage, and initiating apoptosis when DNA damage is irreparable. (NCI04)NCI
code	C2471
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0501270
is someValuesFrom of	nodeID://b644271 nodeID://b644272 nodeID://b644274 nodeID://b726367

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