About: Amiodarone Hydrochloride     Goto   Sponge   Distinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Amiodarone Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Amiodarone Hydrochloride
NSC_Code
  • 85442
UMLS_CUI
  • C0700442
CAS_Registry
  • 19774-82-4
Accepted_Therapeutic_Use_For
  • Ventricular Fibrillation and Ventricular Tachycardia
FDA_UNII_Code
  • 976728SY6Z
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to treat certain types of abnormal heart rhythms that have not gotten better with other drugs. Amiodarone hydrochloride affects the electrical activity of the heart. It is a type of antiarrhythmic agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 39410
PDQ_Closed_Trial_Search_ID
  • 39410
Chemical_Formula
  • C25H29I2NO3.ClH
Legacy_Concept_Name
  • Amiodarone
FULL_SYN
  • amiodarone hydrochloridePTNCI-GLOSSCDR0000642962
  • Amiodarone HydrochloridePTNCI
  • AMIODARONE HYDROCHLORIDEPTFDA976728SY6Z
  • CordaroneBRNCI
  • NexteroneBRNCI
DEFINITION
  • The hydrochloride salt of an iodine-rich benzofuran derivative with antiarrhythmic and vasodilatory activities. As a class III antiarrhythmic agent, amiodarone blocks the myocardial calcium, potassium and sodium channels in cardiac tissue, resulting in prolongation of the cardiac action potential and refractory period. In addition, this agent inhibits alpha- and beta-adrenergic receptors, resulting in a reduction in sympathetic stimulation of the heart, a negative chronotropic effect, and a decrease in myocardial oxygen demands. Amiodarone may cause vasodilation by stimulation of the release of nitric oxide and cyclooxygenase-dependent relaxing endothelial factors.NCI
code
  • C236
sameAs
is someValuesFrom of
is Has_Salt_Form of
is sameAs of
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