About: ZBTB16/RARA Fusion Protein     Goto   Sponge   Distinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • ZBTB16/RARA Fusion Protein
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
Preferred_Name
  • ZBTB16/RARA Fusion Protein
UMLS_CUI
  • C0765587
Legacy_Concept_Name
  • PLZF-RARalpha
FULL_SYN
  • PLZF-RARalphaSYNCI
  • Promyelocytic Leukemia Zinc Finger Protein/Retinoic Acid Receptor Alpha ChimeraSYNCI
  • ZBTB16-RARA Fusion ProteinSYNCI
  • ZBTB16/RARA Fusion ProteinPTNCI
  • PLZF-RARA ChimeraSYNCI
  • PLZF/RARa ProteinSYNCI
  • PLZF-RARalpha Fusion ProteinSYNCI
  • PLZF-RAR-alpha Fusion ProteinSYNCI
  • ZNF145/RARA ChimeraSYNCI
  • Zinc Finger and BTB Domain-Containing Protein 16/Retinoic Acid Receptor Alpha Fusion ProteinSYNCI
DEFINITION
  • A fusion protein encoded by the ZBTB16/RARA fusion gene. This protein is comprised of the N-terminal POZ domain and two of the nine zinc fingers of zinc finger and BTB domain-containing protein 16 fused to the C-terminal DNA and ligand binding domains of the retinoic acid receptor alpha protein.NCI
DesignNote
  • Due to alternative splicing of the ZBTB16 gene, two forms of the ZBTB16/RARA fusion protein can be detected: ZBTB16-RARA Isoform A (735 amino acids, ~81 kDa) is composed of the N-terminal part of zinc finger and BTB domain-containing protein 16 including POZ domain and two of the nine zinc fingers, fused to the DNA and ligand binding domains of the retinoic acid receptor alpha protein; ZBTB16-RARA Isoform B (858 amino acids, ~93 kDa) differs from Isoform A by the inclusion of a 123 amino acid proline-rich region from zinc finger and BTB domain-containing protein 16. (Atlas of Genetics and Cytogenetics in Oncology and Haematology)
code
  • C18292
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