About: Prinomastat     Goto   Sponge   Distinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Prinomastat
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Prinomastat
UMLS_CUI
  • C0919273
CAS_Registry
  • 192329-42-3
FDA_UNII_Code
  • 10T6626FRK
Contributing_Source
  • FDA
ALT_DEFINITION
  • An anticancer drug that belongs to the family of drugs called angiogenesis inhibitors. Prinomastat is a matrix metalloproteinase inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 43058
PDQ_Closed_Trial_Search_ID
  • 43058
Chemical_Formula
  • C18H21N3O5S2
Legacy_Concept_Name
  • Prinomastat
FULL_SYN
  • (3S)-N-Hydroxy-2,2-dimethyl-4-{{4-(4-piridinyloxy)phenyl}sulfonyl}-3-thiomorpholinecarboxamideSNNCI
  • PrinomastatPTNCI
  • prinomastatPTNCI-GLOSSCDR0000046016
  • PrinomastatPTDCP31682
  • AG3340PTNCI-GLOSSCDR0000044862
  • AG3340CNNCI
  • PRINOMASTATPTFDA10T6626FRK
DEFINITION
  • A synthetic hydroxamic acid derivative with potential antineoplastic activity. Prinomastat inhibits matrix metalloproteinases (MMPs) (specifically, MMP-2, 9, 13, and 14), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. As a lipophilic agent, prinomastat crosses the blood-brain barrier. (NCI04)NCI
code
  • C1811
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