About: Topoisomerase II Beta     Goto   Sponge   Distinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Topoisomerase II Beta
equivalentClass
OMIM_Number
  • 126431
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Enzyme
Preferred_Name
  • Topoisomerase II Beta
UMLS_CUI
  • C1504636
Legacy_Concept_Name
  • Topoisomerase-II_Beta
FULL_SYN
  • Topoisomerase (DNA) II Beta 180kDaSYNCI
  • Topo II BetaSYNCI
  • DNA Topoisomerase II, Beta IsozymeSYNCI
  • Topoisomerase (DNA) II Beta (180kD)SYNCI
  • DNA Topoisomerase II, 180 kDSYNCI
  • TOP2BSYNCI
  • Topoisomerase, DNA, II, BetaSYNCI
  • Topoisomerase II BetaPTNCI
Swiss_Prot
  • Q02880
DEFINITION
  • Encoded by human TOP2B Gene (TOPII Family), alternative homodimeric nuclear DNA Topoisomerase II, Beta isoforms: 2 (1626-aa, 183-kD) and 1 (1621-aa) control DNA topology. TOP2B catalyzes transient ATP-dependent double-strand breakage/relaxation and rejoining of negative/positive supercoiled DNA during transcription, replication, chromosome condensation, and chromatid separation. With 72% similarity in TOP2, TOP2A/B N-terminal ATPase and central breakage/reunion domains are conserved; the C-terminal domains differ markedly. The TOP2B C-terminus contains potential phosphorylation sites. TOP2B is a target for several anticancer agents. Mutations are linked with drug resistance and perhaps ataxia-telangiectasia. (from LocusLink, Swiss-Prot, OMIM, and NCI)NCI
  • Both topo II alpha and beta isoforms exhibit ATP-dependent strand passage activity, but they differ in several key aspects. The beta isoform relaxes DNA in a more progressive manner than the alpha isoform and also exhibits a higher optimal KCl requirement. The beta isoform has a molecular weight of 180 KD, and is immunologically distinct as well as exhibits different SV8 proteolytic cleavage pattern from alpha isoform.NCI
code
  • C17802
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