About: Proteasome 26S Subunit Non-ATPase 10     Goto   Sponge   Distinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Proteasome 26S Subunit Non-ATPase 10
rdfs:subClassOf
OMIM_Number
  • 603480
Semantic_Type
  • Amino Acid, Peptide, or Protein
Preferred_Name
  • Proteasome 26S Subunit Non-ATPase 10
UMLS_CUI
  • C0911800
Legacy_Concept_Name
  • Proteasome-26S_Subunit_Non-ATPase-10
FULL_SYN
  • Proteasome 26S Subunit Non-ATPase 10PTNCI
  • 26S Proteasome Regulatory Subunit p28SYNCI
  • PSMD10SYNCI
  • GankyrinSYNCI
  • Hepatocellular Carcinoma-Associated Protein p28-IISYNCI
DEFINITION
  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. This protein is a non-ATPase subunit of the 19S regulator. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. (from LocusLink)NCI
code
  • C17778
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