About: Insulin-Like Growth Factor-Binding Protein 6

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Attributes	Values
rdf:type	Class
rdfs:label	Insulin-Like Growth Factor-Binding Protein 6
equivalentClass	nodeID://b633988
OMIM_Number	146735
Semantic_Type	Amino Acid, Peptide, or Protein Biologically Active Substance
Preferred_Name	Insulin-Like Growth Factor-Binding Protein 6
UMLS_CUI	C0169975
Legacy_Concept_Name	Insulin-Like_Growth_Factor-Binding_Protein-6
FULL_SYN	Insulin-Like Growth Factor Binding Protein 6SYNCI Insulin-Like Growth Factor-Binding Protein 6PTNCI IGFBP6SYNCI IGFBP-6SYNCI IGF Binding Protein 6SYNCI
Swiss_Prot	P24592
DEFINITION	Insulin-like growth factor binding protein 6 (240 aa, 25 kD) is a cellular division process protein that is encoded by the human IGFBP6 gene and has a role in negative regulation of cell proliferation.NCI
DesignNote	IGFBP6 contains a thyroglobulin type-I domain, belongs to the IGFBP family, and may function as an autocrine growth inhibitor. IGFBPs display strong sequence homologies. IGFBPs contain three distinct domains. N-terminal domain 1 and C-terminal domain 3 contain invariant cysteine residues and are the IGF binding domains. Domain 2 generally lacks sequence identity among the IGFBPs. Domain 3 is homologous to the thyroglobulin type I repeat. IGF-I and IGF-II circulate in plasma tightly bound to IGFBPs. IGFs, IGFRs, and IGFBPs regulate cell proliferation and apoptosis and the primary effect of IGFBPs appears to be modulation of IGF activity and control of IGF-mediated cell growth and metabolism. Secreted IGF-binding proteins prolong the half-life of IGFs (somatomedins) and either inhibit or stimulate the growth promoting effects of IGFs by altering the interaction of IGFs with cell surface receptors. (from OMIM 146735, SWISS-PROT P24592 and NCI)
code	C17587
sameAs	Insulin-Like Growth Factor Binding Protein 6
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0028347
is sameAs of	Insulin-Like Growth Factor Binding Protein 6 Insulin-Like Growth Factor Binding Protein 6

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