About: Gastrin Immunotoxin     Goto   Sponge   Distinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Gastrin Immunotoxin
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Gastrin Immunotoxin
UMLS_CUI
  • C0935889
In_Clinical_Trial_For
  • Stomach, Colon, Rectal, Liver, Esophageal, and Pancreatic Cancer.
PDQ_Open_Trial_Search_ID
  • 38352
PDQ_Closed_Trial_Search_ID
  • 38352
Legacy_Concept_Name
  • Gastrin_Immunotoxin
FULL_SYN
  • Anti-Gastrin Therapeutic VaccineSYNCI
  • Neutralize Hormone G17SYNCI
  • Neutralizing G17 HormoneSYNCI
  • GastrimmuneBRNCI
  • G17DT ImmunogenSYNCI
  • Anti-gastrin 17SYNCI
  • G17DTABNCI
  • Gastrin ImmunotoxinPTNCI
DEFINITION
  • An immunotoxin containing an epitope of human gastrin conjugated to diphtheria toxin, with antineoplastic activity. The gastrin epitope in this vaccine is chemically identical or similar to the endogenous gastrin-17 (G-17), a 17-amino acid peptide hormone that stimulates secretion of gastric acid by the stomach. Diphtheria toxin inhibits protein synthesis via modifying translation elongation factor 2 (EF-2). Vaccination with this immunotoxin may elicit production of antibodies against gastrinoma cells overexpressing gastrin, in addition to the toxic effects on protein synthesis exerted by the diphtheria toxin moiety.NCI
code
  • C1692
http://linked.open...y/mesh/hasConcept
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