About: Antibody-Dependent Cellular Cytotoxicity

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Antibody-Dependent Cellular Cytotoxicity
rdfs:subClassOf	Cell-Mediated Cytotoxicity
Semantic_Type	Cell Function
Preferred_Name	Antibody-Dependent Cellular Cytotoxicity
UMLS_CUI	C0003272
ALT_DEFINITION	A type of immune reaction in which a target cell or microbe is coated with antibodies and killed by certain types of white blood cells. The white blood cells bind to the antibodies and release substances that kill the target cells or microbes.NCI-GLOSS
Legacy_Concept_Name	Antibody-Dependent_Cellular_Cytotoxicity
FULL_SYN	ADCCPTNCI-GLOSSCDR0000653101 antibody-dependent cell-mediated cytotoxicityPTNCI-GLOSSCDR0000653102 ADCCABNCI antibody-dependent cellular cytotoxicityPTNCI-GLOSSCDR0000653103 Antibody-Mediated LympholysisSYNCI Antibody-Dependent Cellular CytotoxicityPTNCI
DEFINITION	The target killing of a cell depending on antibody recognition. An antibody is directed to the target by antigen-binding arms and anchors to the killer cell by an Fc receptor. The identity of the target cell varies, but it must possess surface IgG whose Fc portion is intact. The effector "killer" cell possesses Fc receptors. It may be a lymphocyte lacking conventional B- or T-cell markers, or a monocyte, macrophage, or polynuclear leukocyte, depending on the identity of the target cell. The reaction is complement-independent.NCI
code	C16298
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0001370
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